Table 1.

Evolution of sepsis definitions. MAP: mean arterial pressure, SOFA: Sequential Organ Failure Assessment.

1992 SEPSIS—1 Bone et al. [3]	Sepsis Systemic inflammatory response to infection	Severe Sepsis Sepsis associated with organ dysfunction, hypoperfusion, or hypotension	Septic Shock Sepsis-induced hypotension despite adequate fluid resuscitation along with the presence of perfusion abnormalities
2001 SEPSIS—2 Levy et al. [4]	Sepsis A clinical syndrome defined by the presence of both infection and a systemic inflammatory response	Severe Sepsis Sepsis associated with organ dysfunction, hypoperfusion, or hypotension	Septic Shock State of acute circulatory failure characterized by persistent arterial hypotension unexplained by other causes
2016 SEPSIS—3 Singer et al. [5]		Sepsis A life-threatening organ dysfunction caused by a dysregulated host response to infection (SOFA score of ≥2). In-hospital mortality >10%	Septic Shock A subset of sepsis with profound circulatory, cellular, and metabolic abnormalities with higher mortality. Vasopressor requirement (MAP ≥ 65 mmHg) and serum lactate level > 2 mmol/L in the absence of hypovolemia. In-hospital mortality > 40%