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Determination of inhibitory concentration (IC50) for Compounds 21, 24, 28–30 against Epidermal Growth Factor Receptor (EGFR) and BRAFV600E oncogene.
| Compd. | EGFR Inhibition IC50 ± SEM (nM) |
BRAFV600E Inhibition IC50 ± SEM (nM) |
|---|---|---|
| 21 | 72 ± 5 | 73 ± 6 |
| 24 | 73 ± 5 | 77 ± 6 |
| 28 | 70 ± 5 | 69 ± 6 |
| 29 | 75 ± 5 | 80 ± 7 |
| 30 | 68 ± 4 | 65 ± 5 |
| Erlotinib | 80 ± 5 | ± 5 |
