Table 5.
Extensive prediction and analysis of toxicity properties for synthesized hybrid compounds (21–30).
| Comp. ID | FDA Rodent Carcinogenicity (Mouse, Female) |
Rat Maximum Tolerated Dose (Feed) a |
Rat Oral LD50 a |
Ocular Irritancy |
Skin Irritancy |
|---|---|---|---|---|---|
| 21 | Non-Carcinogen | 0.0760 | 1.27741 | Mild | Non-Irritant |
| 22 | Non-Carcinogen | 0.0312 | 8.48863 | Mild | Non-Irritant |
| 23 | Non-Carcinogen | 0.0597 | 1.67537 | Moderate-Severe | Non-Irritant |
| 24 | Non-Carcinogen | 0.0293 | 14.0883 | Mild | Non-Irritant |
| 25 | Non-Carcinogen | 0.0351 | 0.932102 | Mild | Non-Irritant |
| 26 | Non-Carcinogen | 0.0582 | 4.49508 | Mild | Non-Irritant |
| 27 | Non-Carcinogen | 0.0468 | 2.05463 | Mild | Non-Irritant |
| 28 | Non-Carcinogen | 0.0293 | 14.0883 | Mild | Non-Irritant |
| 29 | Non-Carcinogen | 0.0329 | 5.06156 | Mild | Non-Irritant |
| 30 | Non-Carcinogen | 0.0274 | 12.7428 | Mild | Non-Irritant |
| Erlotinib | Non-Carcinogen | 0.0828 | 0.662169 | Mild | Non-Irritant |
a Unit: g/kg body weight.