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. 2023 Aug 25;15(9):1808. doi: 10.3390/v15091808

Figure 2.

Figure 2

Differential expression of six genes located at 1q21.2–q22 in BL-CLs. The figure shows the expression level of BCL9 (A), MCL1 (B), ARNT (C), MLLT11 (D), PBXIP1 (E) and FCRL5 (F) relative to their mRNA level detected in the BL-28, an EBV− BL cell line without 1q aberrations. The localization of the investigated genes, their transcriptional direction (indicated with an arrow) and the BAC clones covering their position are highlighted on the 1q ideogram (G). Expression levels in EBV-negative (EBV−) BL-CLs are shown as empty bars and in EBV-positive (EBV+) BL-CLs as black bars. Note that 4 EBV− and 12 EBV+ BL-CLs without (w/o) 1q gains and 13 EBV− and 8 EBV+ BL-CLs with 1q gains were investigated in this study. Each sample was measured in two independent qPCR experiments prepared as duplicates. *: p < 0.05; **: p < 0.01; ***: p < 0.001; ****: p < 0.0001 (two-way ANOVA followed by Tukey’s multiple comparisons test).