Table 2.

Conformational epitope analysis of the SARS-CoV-2 Omicron subvariants BJ.1, BM.1.1.1, XBB.1.5, and XBB.1.16. The results of the conformational epitope analysis were compared for each mutation, and only matched regions were excerpted. The mutated regions are indicated by red letters. Areas highlighted in light yellow indicate RBD regions.

	BJ.1		BM.1.1.1
Position	Predicted epitopes	Position	Predicted epitopes
147–151	KNNKS	146–152	HENNKSR
182–185	KEGN	182–185	KQGN
437–452	NSNKLDSKPSGNYNYL	439–452	NKLDSKVSGNYNYL
455–460	LFRKSN	457–460	RKSK
474–489	QAGNKPCNGAAGFNCY	472–489	IYQAGNKPCNGVAGSNCY
491–506	PLRSYGFRPTYGVGHQ	498–506	RPTYGVGHQ
703–705	NSV	703–705	NSV
836–842	QYGDCLG	834–841	IKQYGDCL
890–896	AGAALQI	890–896	AGAALQI
1140–1162	PLQPELDSFKEELDKYFKNHTSP	1140–1162	PLQPELDSFKEELDKYFKNHTSP
	XBB.1.5		XBB.1.16
Position	Predicted epitopes	Position	Predicted epitopes
146–151	QKNNKS	147–151	KNNKS
182–185	KEGN	182–185	KEGN
436–452	WNSNKLDSKPSGNYNYL	436–452	WNSNKLDSKPSGNYNYL
455–460	LFRKSK	455–460	LFRKSK
472–494	IYQAGNKPCNGVAGPNCYSPLQS	469–494	STEIYQAGNRPCNGVAGPNCYSPLQS
498–506	RPTYGVGHQ	496–506	GFRPTYGVGHQ
703–705	NSV	703–705	NSV
836–843	QYGDCLGD	834–841	IKQYGDCL
890–895	AGAALQ	890–894	AGAAL
1140–1162	PLQPELDSFKEELDKYFKNHTSP	1140–1162	PLQPELDSFKEELDKYFKNHTSP