Table 4.
Synthetic AMPs point out anti-A. baumannii activity.
| Peptide | Source | Sequence (nº Amino Acid) | Structure | MIC against A. baumannii (μg/mL) | Ref. | |
|---|---|---|---|---|---|---|
| ATBS | MDR | |||||
| AS-CATH8 | Synthetic peptide | KRVNWAKVGRTALKLLPYIFG (21aa) | AH | 0.6 | — | [86] |
| BmKn2-7 | FIKRIARLLRKIF-NH2 (13aa) | AH | 5 | 5–10 | [95] | |
| BmKn2-7R | Synthetic peptide | FIRRIARLLRRIF-NH2 (13aa) | AH | 2.5 | 2.5–5 | |
| BmKn2-7K | FIKKIAKLLKKIF-NH2 (13aa) | AH | 2.5 | 2.5–5 | ||
| BP100 | KKLFKKILKYL (11aa) | AH | — | 4 | [170] | |
| BP214 | Hybrid peptide | KKLFKKILRYL (11aa) | AH | 2 | — | |
| BP214 analogs | KKLFKKILRYL (11aa) analogs | AH | >64 | — | ||
| CA(1–8)-ME(1–12) (CAME) | Chimeric peptide | KWKLFKKIGIGAVLKVLTTG-NH2 (20aa) | AH | 3.12 | 3.12–12.5 | [171] |
| CA(1–8)-MA(1–12) (CAMA) | KWKLFKKIGIGKFLHSAKKF-NH2 (20aa) | AH | 12.5 | 3.12–12.5 | ||
| Cecropin-4 | Synthetic peptide | GWLKKIGKKIERVGQNTRDATIQ AIGVAQQAANVAATLKG (40aa) | AH | 4 | 4 | [172,173] |
| Cecropin A (1–8) melittin (1–10) (CAME) | Hybrid peptide | KWKLFKKIGIGAVLKVLTTG-NH2 (20aa) | AH | 32 | 8–32 | [93] |
| Ceragenins; CSA-192; CSA-131; D-150-177C; HBcARDderivative | Cholic acid synthetic mimics | Steroids compounds | NF | — | — | [174] |
| Chex1-Arg20 amide (ARV-1502) | NA | RPNKPRPYLPRPRPPRPVR-NH2 (19aa) | NF | — | Reduction of bacterial load | [175] |
| D-AP19 | Hybrid peptide | RLFRRVKKVAGKIAKRIWK-NH2 (19aa) | NF | 7.81 | 3.91–15.63 | [176] |
| DGL 13K | Synthetic derived D-enantiomers of GL13K derived from the salivary protein BPIFA2 |
GKIIKLKASLKLL-NH2 (13aa) | NF | — | 8–32 | [177] |
| D-Mt6 | Synthetic peptide | KFKKTAKWLIKSAWLLLKSLALKMK (25aa) | AH | 8 | — | [178] |
| DP7 | Computationally designed | VQWRIRVAVIRK (12aa) | AH | — | 4–16 | [179,180,181] |
| ECPep-D | Synthetic peptide | RPFTRAQWFAIQHISPRTIAMRAINNYRWR (30aa) | NF | 37.57 | — | [182] |
| ECPep-2D-Orn | Synthetic peptide | OPFTOAQWFAIQHISPOTIAMOAINNYOWO (30aa) | NF | 17.53 | — | [182] |
| GW-A2 | GAKYAKIIYNYLKKIANALW (20aa) | AH | 32 | 8–32 | [93] | |
| GW-H1a | Synthetic peptide | GYNYAKKLANLAKKFANALW-NH2 (20aa) | AH | 32 | 8–32 | |
| GW-Q6 | GIKIAKKAITIAKKIAKIYW (20aa) | AH | 16 | 8–16 | ||
| HP(2–9)-MA(1–12) (HPMA) | Chimeric peptide | AKKVFKRLGIGKFLHSAKKF-NH2 (20aa) | AH | 6.25 | 3.12–6.25 | [171] |
| HP(2–9)-ME(1–12) (HPME) | AKKVFKRLGIGAVLKVLTTG (20aa) | AH | 6.25 | 3.12–12.5 | ||
| I16K-piscidin-1 and analogs | Hybrid striped bass Morone saxatilis x M. chrysops | FFHHIFRGIVHVGKTIHRLVTG (22aa) | NF | — | 3.1 | [183] |
| IKR18 | Computationally designed | IKRQYKRFFKLFKWFLKK (18aa) | AH | 1 | — | [184] |
| LJ-hep2(66–86) | Synthetic peptide | IKCKFCCGCCTPGVCGVCCRF (21aa) | NF | — | 1.5–3 | [185] |
| LyeTx I-bPEG | Synthetic peptide | WLTALKFLGKNLGKLAKQQCAKL (PEG) (24aa) |
AH | — | — | [186] |
| mCM11, cecropin–melittin 11 | Synthetic peptide | NH2-WRLFRRILRVL-NH2 (11aa) | AH | 32 | <4–>512 | [187] |
| MSI-78 | Synthetic peptide, magainin analog | GIGLPLLLALLPGLAPVLILLL-NH2 (22aa) | AH | — | 5 | [188] |
| Mt6 | Synthetic peptide | KKFKKTAKWLIKSAWLLLKSLALKMK (26aa) | AH | 8 | — | [178] |
| NCR169C and its substitution derivatives | Synthetic peptide | KSKKPLFKIWKCVENVCVLWYK | AH | 1.6–12.5 MBC | — | [189] |
| Octominin, Octominin-CNPs | Synthetic derived, defensin 3 of Octopus minor | GWLIRGAIHAGKAIHGLIHRRRH (23aa) | AH | — | 5 | [190,191] |
| Octopromycin | Synthetic peptide | N-RRLIRTDTGPIIYDYFKDQLLKKGMVI LRESMKNLKGM-C (38aa) |
AH | — | 50 | [192] |
| OG1410 | ApoE-based synthetic peptide | acetyl-ASAib-LRKL-Aib-KRLL-amide | AH | 16 | 16 | [193] |
| Omega 76-shuft1 | Computationally designed | AFLLKKKKGIIFFEKAKKGK (20aa) | AH | — | 4–16 | [194] |
| Omiganan | Synthetic peptide | ILRWPWWPWRRK-NH2 (12aa) | AH | 32 | — | [88] |
| r-Omiganan | KRRWPWWPWRLI-NH2 (12aa) | AH | 16 | — | ||
| OMN6 | Synthetic peptide | H-M-C-KWKLFKKIEKVGQNIRDGIIKA-GP-AVAVVGQATQIAK-C-NH2 (40aa) | AH | 8 | 4–8 | [195,196] |
| ′Ω17 family peptides | Computationally designed | RKKAIKLVKKLVKKLKKALK (20aa) | AH | 2 | 1–8 | [194] |
| ′Ω76 family peptides | FLKAIKKFGKEFKKIGAKLK (20aa) | AH | 4 | 2–8 | ||
| P10 | Synthetic derivated | LAREYKKIVEKLKRWLRQVLRTLR (24aa) | NF | 4 | 8–32 | [155] |
| P10 + Nisin combined | Synthetic derivated + Lactococcus lactis (Probiotic bacterium) | LAREYKKIVEKLKRWLRQVLRTLR (24aa) + MSTKDFNLDLVSVSKKDSGASPRITSISLCTPGGKTGALNGCNMKTATCHCSIHVSK (34aa) | NF | 1 | 4–16 | |
| PapMA | Hybrid peptide | RWKIFKKIPKFLHSAKKF-NH2 (18aa) | AH | 32 | 16–32 | [197] |
| pepD2 | Computationally designed |
WKKLKKLLKKLKKL-NH2 (14aa) | AH | 8 | - | [198] |
| PLP-3 | Synthetic peptides derived from the innate immune system of vertebrates | ~RRPVCVVPLPRVPCLRRR~ | B- hairpin | 1–2 | 1–2 | [199] |
| PNA (RXR)4 XB | Peptide nucleic acid conjugated to (RXR)4 Phosphorodiamidate Morpholino Oligomers | RXRRXRRXRRXRXB (14aa) | NF | — | 1.25 * | [200] |
| Pro9-3 | Computationally designed |
RLWLAIWRR-NH2 (9aa) | AH | 16 | 8–64 | [201] |
| Pro9-3D | RLWLAIWRR-NH2 (9aa) | AH | 8 | 4–16 | ||
| RR | Computationally designed | WLRRIKAWLRR (11aa) | AH | — | 25–99 | [202,203] |
| RR2 | WIRRIKKWIRRVHK (14aa) | AH | — | 3–6 | ||
| RR-4 | WLRRIKAWLRRIKA (14aa) | AH | — | 3–6 | ||
| R-Pro9-3 | Computationally designed | RRWIALWLR-NH2 (9aa) | AH | 16 | 8–32 | [201] |
| R-Pro9-3D | RRWIALWLR-NH2 (9aa) | AH | 8 | 4–16 | ||
| S4A | NA | IOWAGOLFOLFO-NH2 (12aa) | AH | 100 | 50 | [204] |
| SAAP-148 NPs | Synthetic peptide | LKRVWKRVFKLLKRYWRQLKKPVR (24aa) + NPs | AH | — | — | [205] |
| Scolopendin A2 | Synthetic peptide | AGLQFKVGRIGRLLRK (16aa) | NF | — | 16 | [206] |
| SPO | NA | NINONWNANGNONLNFNONLNFNO-NH2 (22aa) | AH | 100 | 50 | [204] |
| Stapled AMP Mag (i + 4)1, 15(A9 K, B21A, N22 K, S23 K) | NA, based on magainin two structure | Mag(i + 4)1,15(A9K,B21A,N22K,S23K) | complex | — | — | [207] |
| TAT-RasGAP317–326 anticancer peptide | Chimeric (cell penetrating sequence + Src homology sequence) |
G48RKKRRQRRR57 + W317MWVTNLRTD326 | AH | Growth inhibitory effect | — | [208,209] |
| TAT-RasGAP317–326 | Chimeric peptide | G48RKKRRQRRR57 (10aa) | NF | — | — | [210] |
| TP2-5 | Computationally designed | KKCIAKAILKKAKKLLKKLVNP (22aa) | AH | 3.125 | 1.56–3.125 | [211] |
| TP2-6 | KKCIAKAILKKAKKLLKDLVNP (22aa) | AH | 3.125 | 3.125–12.5 | ||
| Trichogin analogs | Synthetic peptide | 1-Oct-Aib-Gly-Leu-Aib-Gly-Gly-Leu-Aib-Gly-Ile-Lol | >128 | — | [212] | |
| zp3 | Synthetic peptide | GIIAGIIIKIKK-NH2 (12aa) | AH | 4 | — | [213] |
AH, α-helical; BS, β-sheet; NA, unavailable; *, result in µM; aa, amino acid; >, bigger then; <, less than; NF, not found; NPs, nanoparticles; Ref., reference.