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. 2023 Sep 16;15(9):2332. doi: 10.3390/pharmaceutics15092332

Figure 1.

Figure 1

Structures and oxidative degradation products of PS20 and PS80. (A) General structure of PS20 with potential radical initiation sites on the POE units (1, blue). (B) General structure of PS80 with potential radical initiation sites on the POE units (1, blue) and near the unsaturated site of oleic acid (2, red). According to the pharmacopoeias, x + y + z + w = 20. (C) Selected degradation products of polysorbate due to oxidation. Non-esterified products are illustrated. The double bond increases the variety of possible degradants of a PS molecule. Some of the molecules are not drawn to scale or with the corresponding isomer with respect to the double bond to save space.