Table A5.
Case 1.
| Treatment Day | Day 1 | Day 2 | Day 3 | Day 4 | Day 5 |
|---|---|---|---|---|---|
| Date | 2 March 2022 | 3 March 2022 | 4 March 2022 | 5 March 2022 | 6 March 2022 |
| Symptoms | None | None | None | Abdominal pain and nausea relieved after meal and antacid |
Fever, headache, and abdominal pain |
| General condition | Good | Good | Good | Good | Slightly weaker, outdoor activity is impaired |
| MetHb | 0.4 (during enrolment) |
− | − | − | 4.9 |
| Temperature (°C) | − | − | − | − | 36.7 |
| Heart rate (beats/min) |
82 | 101 | 92 | 95 | 116 |
| Respiratory rate (breaths/min) |
18 | 19 | 24 | 21 | 20 |
| Primaquine exposure (mg/kg) |
1.1 | 0.9 | 0.9 | 0.9 | Stopped |
| Hb (g/dL) | 12.0 (during enrolment) |
12.1 | 10.6 | 10.8 | 8.3 |
| Hillmen | 2 | 2 | 3 | 4 | 5 |
| Urine dipstick | Blood trace, urobilinogen 0.2 E.U./dL | No blood, urobilinogen 0.2 E.U./dL |
No blood, urobilinogen 1.0 E.U./dL |
Blood trace, urobilinogen 1.0 E.U./dL |
Blood trace, urobilinogen 2.0 E.U./dL |