Table A7.

Case 3.

Treatment Day	Day 1	Day 2	Day 3	Day 4	Day 5	Day 6	Day 7	Day 8
Date	19 December 2017	20 December 2017	21 December 2017	22 December 2017	23 December 2017	24 December 2017	25 December 2017	26 December 2017
Symptoms	None	Fever	None	None	−	−	−	Fever, nausea over 3 days
General condition	Good	Good	Good	Good	−	−	−	Pale, jaundice, right upper quadrant abdominal pain
metHb (%)	0.4	0.5	0.1	2.5	−	−	−	1.7
Temperature (°C)	36.9	37.2	36.7	37.1	−	−	−	37.8
Heart rate (beats/min)	84	80	75	78	−	−	−	102
Respiratory rate (breaths/min)	25	22	24	26	−	−	−	22
Primaquine exposure (mg/kg)	0.27	0.27	0.27	0.27	0.27	0.27	0.27	Stopped
Hb (g/dL)	11.8	9.7	9.3	9.2	−	−	−	6.0
Hillmen	−	−	−	2	−	−	−	5
Urine dipstick	−	−	−	Urobilinogen 0.2 E.U./dL (3.2 µmol/L)	−	−	−	Urobilinogen 8 E.U./dL (131 µmol/L)