CI	confidence interval
RCTs	randomized controlled trials
MR	Mendelian randomization
IVs	instrumental variables
SNPs	single-nucleotide polymorphisms
GWAS	genome-wide association study
LD	linkage disequilibrium
MAF	minor allele frequencies
F	F-statistics
IVW	inverse variance weighted
FDR	false discovery rate
q	q-value
MR-PRESSO	MR Pleiotropy RESidual Sum and Outlier
OR	odds ratio
CRPC	castration-resistant prostate cancer
SCFAs	short-chain fatty acids
IGF-1	insulin growth factor 1
Tregs	regulatory T cells
PSA	prostate-specific antigen