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Activity of derivatives 2c, 2e, and 2m on STO cells xenotransplanted in athymic nude mice.
| Compound | TVI (%) a | CR b | BWL (%) c | TOX d |
|---|---|---|---|---|
| 2c | 73 * | 2/8 | 4 | 0/8 |
| 2e | 75 ** | 2/8 | 1 | 0/8 |
| 2m | 58 * | 2/8 | 7 | 0/8 |
a Tumour volume inhibition (%) in treated vs. control mice, determined 17 days after the end of drug treatment (day 35). b Complete response, disappearance of tumour induced by treatment. c BWL, body weight loss induced by treatment (%). d Toxic death on treated animals. ** p < 0.01, * p < 0.05.
