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In Vitro kinase inhibitory properties of derivatives 2c, 2e, and 2m.
| Protein Kinase | IC50 (µM) a | ||
|---|---|---|---|
| 2c | 2e | 2m | |
| CDK1 | 0.89 ± 0.07 | 0.75 ± 0.03 | 0.86 ± 0.04 |
| GSK3β | 42.18 ± 3.28 | 40.18 ± 2.94 | 35.68 ± 1.69 |
a Concentration of drug required to inhibit by 50% (IC50) the activity of CDK1 and GSK3β. The data represent mean values ± SD of at least three independent experiments.
