Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Cytotoxic activity and the selectivity index (SI) of the synthesized compounds 2n–q against MCF-7 cancer cell line.
| Compound | Intestinal Normal-like Caco-2 Cells LC50 (µM) a |
MCF-7 GI50 (µM) b | SI |
|---|---|---|---|
| 2n | >100 | 0.05 | ND c |
| 2o | 96.1 ± 3.1 | 2.09 | 46 |
| 2p | 71.4 ± 2.1 | 1.74 | 41 |
| 2q | 83.3 ± 2.5 | 1.79 | 46 |
a LC50 concentration which is lethal to 50% of the normal cells compared to untreated controls; b GI50 Concentration (µM) that inhibits 50% net cell growth; c ND, not determined.
