Table 9.
In vitro inhibition of cancer cell lines growth by compounds 3a–h.
| Cell Line | GI50 (µM) a | |||||||
|---|---|---|---|---|---|---|---|---|
| 3a | 3b | 3c | 3d | 3e | 3f | 3g | 3h | |
| Leukaemia | ||||||||
| CCRF-CEM | 2.02 | 1.78 | 1.83 | 2.15 | 1.30 | 0.36 | 1.74 | 1.96 |
| HL-60(TB) | 2.03 | 1.94 | 1.68 | 1.96 | 1.71 | 1.48 | 1.76 | 1.93 |
| K-562 | 1.76 | 2.09 | 0.72 | 1.90 | 0.24 | 0.24 | 0.46 | 1.70 |
| RPMI82226 | 2.00 | 1.76 | 1.83 | 1.84 | 1.58 | 1.57 | 1.77 | 1.98 |
| Colon Cancer | ||||||||
| HCC-2998 | 1.22 | 1.26 | 1.85 | 1.89 | 1.76 | 1.90 | 1.64 | 1.86 |
| HCT-116 | 1.61 | 0.93 | 1.69 | 1.90 | 1.21 | 0.18 | 1.63 | 1.66 |
| HCT-15 | 1.37 | 1.51 | 1.25 | 1.54 | 1.35 | 1.75 | 1.33 | 1.68 |
| HT29 | 1.82 | 1.98 | 1.20 | 1.43 | 1.59 | 1.60 | 1.44 | 1.47 |
| KM12 | 1.11 | 1.00 | 1.73 | 1.84 | 1.71 | 1.97 | 1.63 | 1.79 |
| SW-620 | 2.03 | 1.85 | 1.75 | 1.96 | 1.52 | 1.85 | 1.65 | 1.88 |
| Breast Cancer | ||||||||
| MCF-7 | 0.30 | 0.32 | 1.47 | 1.70 | 1.33 | 1.78 | 1.23 | 1.93 |
| MDA-MB-231/ATCC | 1.56 | 1.47 | 1.45 | 1.83 | 1.41 | 1.66 | 1.55 | 1.75 |
| HS 578T | 1.93 | 2.16 | 2.03 | 2.21 | 1.94 | 2.23 | 2.21 | 2.36 |
| BT-549 | 9.00 | 1.68 | 1.81 | 1.80 | 1.93 | 1.61 | 1.80 | 1.71 |
| MDA-MB-468 | 0.40 | 0.27 | 0.44 | 1.62 | 1.38 | 1.79 | 1.40 | 1.86 |
a Concentration (µM) that inhibits 50% net cell growth.