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. 2023 Sep 5;28(18):6450. doi: 10.3390/molecules28186450

Table 11.

Overview of the results of the in vitro anti-tumour screening for compounds 4a, 4b, 5a, 6a, and 7a7g.

Thiazole Derivative N° Cell Lines Tested N° Active Cell Lines GI50 Range (µM) a
4a 60 60 0.03–13.0
4b 59 59 0.04–14.2
5a 54 48 0.81–27.7
6a 59 59 0.93–4.70
7a 58 29 4.11–6.89
7b 59 59 4.45–5.98
7c 59 59 4.63–5.28
7d 60 60 4.87–7.50
7e 60 42 4.03–6.11
7f 59 9 4.01–7.56
7g 59 59 4.64–5.59

a Concentration range that inhibits 50% net cell growth.