Table 11.
Thiazole Derivative | N° Cell Lines Tested | N° Active Cell Lines | GI50 Range (µM) a |
---|---|---|---|
4a | 60 | 60 | 0.03–13.0 |
4b | 59 | 59 | 0.04–14.2 |
5a | 54 | 48 | 0.81–27.7 |
6a | 59 | 59 | 0.93–4.70 |
7a | 58 | 29 | 4.11–6.89 |
7b | 59 | 59 | 4.45–5.98 |
7c | 59 | 59 | 4.63–5.28 |
7d | 60 | 60 | 4.87–7.50 |
7e | 60 | 42 | 4.03–6.11 |
7f | 59 | 9 | 4.01–7.56 |
7g | 59 | 59 | 4.64–5.59 |
a Concentration range that inhibits 50% net cell growth.