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Cytotoxic activity of compounds 7b–d,7g in MiaPaCA-2 and STO cell lines.
| Compound | IC50 (µM) a | |
|---|---|---|
| MiaPaCA-2 | STO | |
| 7b | 41.6 ± 2.4 | 17.2 ± 2.9 |
| 7c | 5.7 ± 0.8 | 0.83 ± 0.04 |
| 7d | 4.3 ± 0.6 | 0.41 ± 0.06 |
| 7g | 39.6 ± 3.9 | 5.7 ± 0.8 |
a Concentration of drug required to inhibit growth by 50% as determined by SRB assay after 72 h continuous exposure to each compound; the data represent mean values ± SD of at least three independent experiments.
