Table 13.

Kinase inhibition by compounds 7b–d,6g.

Compound	IC50 (µM) a
	CDK1	CDK5	GSK3β
7b	33.27 ± 2.97	>50.0	>50.0
7c	0.41 ± 0.08	>50.0	>50.0
7d	0.85 ± 0.13	>50.0	>50.0
7g	45.93 ± 4.19	>50.0	>50.0
Purvanalol A	0.73 ± 0.06	>50.0	>50.0
Roscovitine	0.59 ± 0.08	>50.0	>50.0

^a Inhibitor concentration at which enzyme activity is decreased by 50%; data represent the mean ± SD of at least three independent experiments.