Table 19.

In vitro activity of derivatives 14a–e towards 10 human tumour cell lines.

Compound	IC50 (µg/mL)	Active/Total a			Tumour Selectivity b
		1 (µg/mL)	10 (µg/mL)	100 (µg/mL)
14a	9.6	0/10 (0%)	2/10 (20%)	10/10 (100%)	1/10
14b	44.5	0/10 (0%)	0/10 (0%)	7/10 (70%)	0/10
14c	17.3	0/10 (0%)	1/10 (10%)	7/10 (70%)	2/10
14d	24.5	0/10 (0%)	0/10 (0%)	7/10 (67%)	1/10
14e	43.2	0/10 (0%)	0/10 (0%)	3/10 (30%)	1/10

^a Responsive (T/C < 30%)/total cell lines. ^b Selective (individual IC₇₀ < 1/3 mean IC₇₀)/total cell lines.