. 2023 Sep 5;28(18):6450. doi: 10.3390/molecules28186450

Table 20.

Cytotoxicity of oxadiazoles 15a–m against a panel of human cancer cell lines: pancreas (AsPC1), prostate (DU145 and PC3), cervical (HeLa), breast (MDA-MB-231), and ovarian (OVCAR).

Compounds	R	R₁	R₂	R₃	R₄	IC₅₀ (µM) ^a
Compounds	R	R₁	R₂	R₃	R₄	AsPc1	DU145	PC3	MDA-MB-231	OVCAR	HeLa
15a	H	H	H	H	H	0.46	0.23	8.43	0.09	0.10	0.53
15b	Br	H	H	H	H	0.20	0.02	0.25	0.24	0.15	0.02
15c	OCH₃	H	H	H	H	0.06	0.72	0.11	0.90	0.38	66.79
15d	H	F	H	H	H	0.31	9.79	0.29	4.34	0.31	6.86
15e	Br	H	H	F	H	0.45	0.08	4.55	0.20	0.23	0.06
15f	OCH₃	H	H	F	H	1.68	0.42	0.10	6.44	2.91	52.90
15g	H	F	H	F	H	0.20	0.15	1.09	0.21	0.15	0.06
15h	H	H	CH₃	H	CH₃	0.10	0.52	0.12	15.71	0.97	4.55
15i	H	H	4-ClC₆H₄CH₂	H	H	2.47	0.37	7.11	126.3	0.16	0.73
15j	H	H	4-CH₃OC₆H₄CH₂	H	H	0.05	0.54	3.33	168.9	0.10	5.94
15k	Br	H	4-ClC₆H₄CH₂	H	H	0.43	0.11	0.24	0.86	0.27	8.10
15l	H	F	4-ClC₆H₄CH₂	H	H	1.60	0.14	0.05	2.58	0.24	0.96
15m	H	H	4-CH₃OC₆H₄CH₂	H	H	0.07	0.10	0.14	17.22	0.11	1.20

^a IC₅₀ values were obtained using a dose–response curve by nonlinear regression using GraphPad Prism 5.0 for curve fitting. For all data, standard error of the mean (SEM) values were ±<10%.