Table 21.

Cytotoxicity of oxadiazoles 16a–i against a panel of human cancer cell lines: lung (A549), breast (MDA-MB-231 and MCF-7), and cervical (HeLa).

Compound	R	R1	R2	IC50 (µM)
				A549	MDA-MB-231	MCF-7	HeLa
16a	Br	CH3	H	- a	-	30.9 ± 0.48	14.8 ± 0.39
16b	Br	CH3	Br	-	38.9 ± 0.85	24 ± 0.5	19.5 ± 0.43
16c	H	CH3	OCH3	-	-	32.2 ± 0.9	42.3 ± 0.96
16d	H	CH3	NO2	-	-	19.2 ± 0.8	33.2 ± 0.45
16e	Br	CH3	OCH3	24.2 ± 0.89	12.17 ± 1.1	1.8 ± 0.9	9.23 ± 0.58
16f	H	H	H	-	-	24.5 ± 0.9	9.4 ± 0.37
16g	H	H	Br	-	-	-	16.3 ± 0.33
16h	H	H	NO2	3.3 ± 0.85	10.23 ± 1.3	2.6 ± 0.89	6.34 ± 0.56
16i	Br	H	H	-	-	-	19.8 ± 0.45

^a- no activity.