Table 22.
Cytotoxicity of oxadiazoles 17a,b against a panel of human cancer cell lines: breast (MCF-7), colon (HCT-116 and CaCo2), and cervical (HeLa).
| Compound | R | R1 | IC50 (µM) a | |||
|---|---|---|---|---|---|---|
| MCF-7 | HCT-116 | CaCo2 | HeLa | |||
| 17a | Cl | Br | 0.65 ± 0.05 | 1.93 ± 0.06 | 1.06 ± 0.09 | 10.56 ± 0.98 |
| 17b | OCH3 | Br | 2.41 ± 0.23 | 3.55 ± 0.1 | 3.33 ± 0.25 | 13.96 ± 1.41 |
a IC50 value was calculated by plotting the percentage viability versus concentration on a logarithmic graph. Results are the mean values SD (standard deviation) of three separate experiments carried out in triplicate.