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In vitro GSK3β inhibitory activities of aminopyrazole derivatives 24 and 25.
| Compound | R | R1 | IC50 (µM) a |
|---|---|---|---|
| 24a | 5-F | CH3 | 1.28 ± 0.18 |
| 24b | 5-Br | CH3 | 1.93 ± 0.22 |
| 24c | 5-OCH3 | CH3 | 1.76 ± 0.19 |
| 25a |
|
— | 1.46 ± 0.04 |
| 25b | H | — | 1.48 ± 0.30 |
a The data represent mean values ± SEM of at least three independent experiments.
