Table 2. Single crystal structures for DNA·RNA hybrid/chimer duplexes.
| Sequencea | Structureb | Crystal packing | Reference |
|---|---|---|---|
| Hybrid | |||
| (gaagaagag)·(CTCTTCTTC) | A-form | Abutting | This work |
| (gaagaagaa)·(TTCTTBr5CTTC) | A-form | Abutting | (4) |
| (gaagagaagc)·(GCTTCTCTTC) | A-form | Abutting | (15) |
| Hammerhead ribozyme with a DNA substrate | A-form | Abutting and end-to-end stacking | (16) |
| (uucgggcgcc)·(GGCGCCCGAA) | RNA: C3′-endo | Abutting and end-to-end stacking | (17) |
| DNA: C2′-endo for AA | |||
| C3′-endo for others | |||
| Chimer | |||
| (gcgTATACGC)2 | A-form | Abutting | (18) |
| (GCGTaTACGC)2 | A-form | Abutting | (19) |
| (gCGTATACGC)2 | A-form | Abutting | (19) |
| (CCGGCgCCGG)2 | A-form | Abutting | (20) |
| (gcgTATACCC)·(GGGTATACGC) | A-form | Abutting | (21) |
| (gcaguggc)·(gccaCTGC) | A-form | Abutting and end-to-end stacking | (22) |
aRNA is in lowercase letters and underlined.
bDiscussions are restricted to the hybrid portion of the duplex.