TABLE 1.

Top 15 upregulated genes in mock, infected, and bystander clusters for the HAstV-1 Caco-2 single-cell RNA sequencing data set at 24 hpi

Gene	Cluster	avg_log2FC	pct.1	pct.2	p_val_adj
ITM2B	Mock	0.656933	0.785	0.428	0
RPL17	Mock	0.529021	0.943	0.716	0
S100A10	Mock	0.52348	0.916	0.681	0
CD99	Mock	0.5072	0.972	0.786	0
H2AFZ	Mock	0.701308	0.649	0.268	8.89E−265
EPCAM	Mock	0.635118	0.698	0.345	1.78E−252
MIF	Mock	0.636467	0.625	0.27	2.30E − 220
SCD	Mock	0.563748	0.689	0.377	8.00E−201
PTMA	Mock	0.548704	0.725	0.397	1.02E−186
NME2	Mock	0.536384	0.663	0.357	1.60E−171
CST3	Mock	0.544066	0.678	0.387	3.19E−171
TUBA1B	Mock	0.565624	0.604	0.28	6.11E−167
PDIA6	Mock	0.534388	0.433	0.15	8.62E−149
PFN1	Mock	0.526555	0.53	0.247	9.26E−148
TPI1	Mock	0.510377	0.522	0.244	1.72E−138
HAstV1	Infected	2.749525	1	0	0
ZC3HAV1	Infected	1.110522	0.792	0.255	0
IFIT3	Infected	1.061962	0.517	0.039	0
IRF1	Infected	0.981695	0.523	0.041	0
IFI6	Infected	0.981588	0.784	0.3	0
DTX3L	Infected	0.967167	0.776	0.276	0
KLF6	Infected	0.93654	0.687	0.229	0
APOL2	Infected	0.933543	0.558	0.129	0
HELZ2	Infected	0.92706	0.509	0.04	0
DDX58	Infected	0.89635	0.464	0.041	0
PARP14	Infected	0.877263	0.722	0.276	0
ISG15	Infected	0.87406	0.495	0.058	0
TFAP2C	Infected	0.859227	0.731	0.335	0
IFIT2	Infected	0.856451	0.342	0.012	0
STAT2	Infected	0.849258	0.8	0.407	0
HMGB1	Bystander	0.315939	0.894	0.735	4.06E−19
HMGN2	Bystander	0.336253	0.82	0.657	3.40E−18
TUBA1B	Bystander	0.427122	0.707	0.439	6.20E−18
SSR3	Bystander	0.329197	0.749	0.6	9.21E−17
EBP	Bystander	0.31393	0.848	0.688	1.71E−15
PARP14	Bystander	0.405334	0.71	0.46	5.39E−15
SYNC	Bystander	0.401247	0.587	0.372	3.74E−14
AC091607.2	Bystander	0.349163	0.668	0.496	2.80E−12
TUBB	Bystander	0.381438	0.541	0.337	4.94E−12
PTMA	Bystander	0.315548	0.731	0.562	2.88E−11
RRM2	Bystander	0.407369	0.516	0.304	2.98E−11
PA2G4	Bystander	0.339074	0.65	0.439	5.45E−11
IFI6	Bystander	0.367067	0.746	0.501	1.96E−10
IFIT1	Bystander	0.327753	0.325	0.154	2.79E−10
MYADM	Bystander	0.347887	0.583	0.412	4.98E−09