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Binding kinetics and affinity of 7D12 and 7D12-s775z to human and canine recombinant EGFR via SPR analysis.
| Human recombinant EGFR | Canine recombinant EGFR | |||||
|---|---|---|---|---|---|---|
| kon (106 M-1s-1) | koff (s-1) | KD (nM) | kon (106M-1s-1) | koff (s-1) | KD (nM) | |
| 7D12 | 0.674 | 0.004 | 5.4 | 1.091 | 0.032 | 29.3 |
| 7D12-s775z | 0.410 ± 0.072 | 0.004 ± 0.001 | 11.1 ± 2.5 | 0.907 ± 0.110 | 0.028 ± 0.001 | 31.6 ± 3.9 |
