Table 4.

Mediation and Multivariable Analyses of association between and OD and cognitive functioning by Adherence to Dietary Pattern 3 (Monosaturated Fatty Acids and Polysaturated Fatty Acids).

	Mediation Analysis
	Beta (95% CI)	p-Value
CERAD-WL
Model 1
ACME	−0.12 (−0.23, −0.04)	<0.001 ***
ADE	−1.68 (−2.23, −1.1)	<0.001 ***
Total Effect	−1.80 (−2.37, −1.25)	<0.001 ***
Prop. Mediated	0.07 (0.03, 0.14)	<0.001 ***
CERAD-DR
Model 2
ACME	−0.05 (−0.09, −0.01)	0.004 **
ADE	−0.99 (−1.27, −0.72)	<0.001 ***
Total Effect	−1.04 (−1.32, −0.78)	<0.001 ***
Prop. Mediated	0.05 (0.02, 0.12)	0.003 **
DSST
Model 3
ACME	−0.35 (−0.55, −0.16)	<0.001 ***
ADE	−3.99 (−6.01, −1.9)	<0.001 ***
Total Effect	−4.34 (−6.44, −2.23)	<0.001 ***
Prop. Mediated	0.08 (0.04, 0.14)	<0.001 ***
AF
Model 4
ACME	−0.14 (−0.26, −0.04)	0.008 **
ADE	−2.05 (−2.75, −1.36)	<0.001 ***
Total Effect	−2.19 (−2.9, −1.49)	<0.001 ***
Prop. Mediated	0.06 (0.02, 0.12)	0.008 **

Models were adjusted for age, gender, race, income-to-poverty ratio, education, body mass index, total energy intake, and smoking status. In these analyses, DP3 was modeled continuously. ** p-value < 0.005 *** p-value < 0.0005. Abbreviations: CERAD: Consortium to Establish a Registry for Alzheimer’s Disease; CERAD-WL: CERAD word learning; CERAD-DR: CERAD delayed word recall; CI: confidence interval; DSST: Digit Symbol Substitution Test.