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. 2023 Aug 22;15(9):2174. doi: 10.3390/pharmaceutics15092174

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Relationship between the relative occurrence of co-crystals (AB neutral (grey)) and salts (A⁻B⁺ ionic (orange)) and the calculated ΔpK_a. Reprinted with permission from ref. [71]. Copyright 2012 Royal Society of Chemistry.