Representative CLSM images (recorded in fluorescence (A,B) and reflectance (C) regimes) of skin penetration. (A): Penetration of curcumin-labeled almond oil measured in vivo in human SC (white areas, excitation/emission at 488/590 nm), reprinted with permission from Ref. [92]; (B): Penetration of biocompatible hydroxyl ethyl starch nanocapsules measured ex vivo in porcine skin (fluorescence depicted in red, excitation/emission at 555/593 nm), reprinted under CC BY 4.0 license from Ref. [93]; (C): Penetration of gold microparticles measured in vivo in human epidermis (white spot areas, reflectance regime at 785 nm), reprinted with permission from Ref. [94]. Scale bar: 100 µm.