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. Author manuscript; available in PMC: 2023 Sep 28.
Published in final edited form as: Immunohorizons. 2022 Dec 1;6(12):851–863. doi: 10.4049/immunohorizons.2200075

FIG 4.

FIG 4

Age-dependent differences in transcriptomic responses in the trachea reveal downregulated interferon (IFN) stimulated genes in adult macaques. (A) Hallmark pathways significantly (p-value ≤0.05) enriched among downregulated genes in adult compared with infant macaques 14 days after SARS-CoV-2 infection. (B) Heat map of differentially expressed IFN stimulated genes from Interferon Alpha Response and Interferon Gamma Response Hallmark pathways (p-value ≤0.05). Blue represents relative upregulation of gene expression and white represents relative downregulation of gene expression. Genes are arranged by log2 fold change with the largest log2 fold change to the left and the smallest log2 fold change to the right.