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. Author manuscript; available in PMC: 2024 Oct 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2023 Aug 17;43(10):2058–2067. doi: 10.1161/ATVBAHA.123.319341

Figure 1.

Figure 1.

Flow chart of study design. 130,091 UK Biobank participants with exome sequences available were classified by molecular and genetic determinants of severe hypercholesterolemia. 11,738 participants with severe hypercholesterolemia were classified into subtypes based on the presence of corresponding determinants. Those without a determinant were classified as the non-genetic subtype. LDL-C = low-density lipoprotein cholesterol; HDL = high-density lipoprotein cholesterol; BP = blood pressure; FH = familial hypercholesterolemia; PRS = polygenic risk score; Lp(a) = lipoprotein (a); CAD = coronary artery disease.