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Severe hypercholesterolemia stratified by LDL-C and genetic subtype. Kaplan-Meier plots show 10-year incident CAD risk among UK Biobank participants A) binned into three groups of increasing LLM-adjusted LDL-C: 190-210 mg/dL (reference), 210-230 mg/dL and >230 mg/dL and B) binned by non-genetic (reference) and genetic subtypes. Cox proportional-hazard ratios and 95% confidence intervals adjusted for CAD risk factors and principal components of ancestry are shown.
