Table 2.
Clinical characteristics and comorbidities of subtypes in the severe hypercholesterolemia cohort (n = 11,738).
| Non-genetic | Monogenic | Two-hit | Polygenic | Elevated Lp(a) | |
|---|---|---|---|---|---|
| Sample Size (N) | 6528 | 204 | 913 | 2070 | 2023 |
| Prevalence | 1 in 2 | 1 in 58 | 1 in 13 | 1 in 6 | 1 in 6 |
| Age (Mean (SD)) | 58.88 (6.99) | 56.9 (7.23) | 58.1 (7.31) | 58.02 (7.21) | 59.07 (6.67) |
| Sex (% Female) | 55.5 | 64.7 | 57.6 | 54.9 | 61.2 |
| LDL-C (est. untreated) (mg/dL) ((Mean (SD)) | 210.19 (21.46) | 236.1 (40.46) | 214.74 (24.74) | 212.68 (23.37) | 211.45 (22.58) |
| BMI (Mean (SD)) | 28.13 (4.24) | 27.57 (4.92) | 27.68 (4.5) | 28.03 (4.3) | 27.99 (4.43) |
| Systolic BP (mmHg) (Mean (SD)) | 143.04 (18.42) | 137.98 (18.82) | 141.21 (18.71) | 141.47 (18.52) | 143.02 (18.7) |
| HDL-C (mg/dL) (Mean (SD)) | 57.14 (13.11) | 55.67 (11.78) | 59.47 (14.45) | 57.33 (12.75) | 59.18 (13.59) |
| Triglycerides (mg/dL) (Mean (SD)) | 194.44 (74.71) | 146.53 (71.81) | 173.15 (72.44) | 187.83 (74.6) | 182.92 (72.35) |
| BP meds (%) | 23.7 | 20.1 | 20.4 | 19.6 | 26.1 |
| Smoking (%) | 11.3 | 8.3 | 10.5 | 9.6 | 9.7 |
| Cholesterol-lowering medication (%) | 29.8 | 56.4 | 32 | 28.1 | 32.5 |
| AHA Lifestyle Score (Mean (SD)) 1 | 0.99 (0.44) | 1.06 (0.49) | 1.01 (0.45) | 1.02 (0.43) | 1.03 (0.44) |
| Townsend Deprivation Index (Mean (SD)) 2 | −1.58 (2.9) | −1.47 (3.09) | −1.61 (2.94) | −1.6 (2.89) | −1.55 (2.82) |
| Prevalent T1D (%) | 14/6528 (0.2) | 2/204 (1) | 5/913 (0.5) | 2/2070 (0.1) | 4/2023 (0.2) |
| Prevalent T2D (%) | 18/6514 (0.3) | 0/202 (0) | 3/908 (0.3) | 3/2068 (0.1) | 4/2019 (0.2) |
| Prevalent CAD (%) | 2 | 3.9 | 1.4 | 1.7 | 2.9 |
| Prevalent CVD (%) | 6.7 | 8.3 | 4.9 | 4.7 | 6.6 |
| Prevalent PAD (%) | 0.4 | 1 | 0.5 | 0.1 | 0.5 |
| Prevalent AVS (%) | 0.2 | 0.5 | 0.1 | 0.1 | 0.2 |
1
AHA Lifestyle Score: A higher score indicates a more ideal lifestyle (0 = poor, 1 = intermediate, 2 = ideal).
2
Townsend Deprivation Index: A higher (less negative) score corresponds to a lower socioeconomic status.