Table 3.
Adjusteda 102-month restricted mean number of months, and differences in restricted mean months (95% confidence intervals),b spent in each of the HIV care continuum stages by baseline alcohol use among 1781 antiretroviral therapy-naïve persons who enrolled in the Center for AIDS Clinical Research Network of Integrated Clinical Systems, 2011–2019, and who self-reported alcohol consumption within 1 year of enrollment
| Alcohol Use | Difference | |||||
|---|---|---|---|---|---|---|
| HIV care continuum stages | None | Moderatec | Unhealthyc | Moderate – None | Unhealthy – None | Unhealthy – Moderate |
| In care, not ART initiated | 5.7 (4.5, 6.9) | 5.6 (4.9, 6.7) | 6.1 (5.3, 7.4) | −0.1 (−1.5, 1.7) | 0.4 (−0.9, 2.3) | 0.5 (−0.8, 1.9) |
| Lost to clinic before ART initiation | 2.2 (0.8, 3.7) | 4.1 (2.7, 5.9) | 2.7 (1.6, 4) | 1.9 (−0.1, 4.2) | 0.5 (−1.3, 2.4) | −1.5 (−3.5, 0.4) |
| Dead before ART initiation | 0.2 (0, 0.5) | d | 0.1 (0, 0.4) | −0.2 (−0.5, 0.0) | 0.0 (−0.5, 0.3) | 0.1 (0.0, 0.4) |
| In care, not virally suppressed | 8.2 (6, 9.7) | 7.2 (5.9, 8.7) | 6 (4.8, 7.2) | −0.9 (−3.0, 1.7) | −2.2 (−4.1, 0.3) | −1.2 (−3.2, 0.5) |
| In care, virally suppressed | 61.7 (58.3, 67) | 59.7 (55.8, 62.9) | 60.3 (56.7, 63.6) | −2.0 (−9.1, 2.2) | −1.5 (−8.0, 3.2) | 0.5 (−4.1, 5.8) |
| Lost to clinic after ART initiation | 20.6 (16.3, 24.1) | 23.8 (20.8, 26.8) | 24.9 (21.9, 28.1) | 3.3 (−1.4, 8.7) | 4.3 (−0.2, 9.7) | 1.1 (−3.1, 5.5) |
| Dead after ART initiation | 3.5 (2, 5.1) | 1.5 (0.6, 3) | 2 (0.6, 3.3) | −2.0 (−3.8, 0.1) | −1.5 (−3.7, 0.4) | 0.5 (−1.6, 2.0) |
Abbreviations: ART, antiretroviral therapy; Mod., moderate
Adjusted for site, gender, race, HIV risk factor and VACS 2.0 score. The VACS 2.0 score incorporates age, sex, body mass index, CD4 cell count, estimated glomerular filtration rate (calculated from serum creatinine, age, sex, and race), HIV RNA, hemoglobin, alanine transaminase, aspartate aminotransferase, platelet count, white blood cell count, albumin, and hepatitis C virus infection.
Difference estimates may differ slightly from direct subtractions of alcohol use estimates due to rounding
Moderate alcohol consumption defined as AUDIT-C score >0 and <3 for women and >0 and <4 for men; unhealthy alcohol consumption defined as AUDIT-C score ≥3 for women and ≥4 for men.
Among patients in the Moderate alcohol use group at baseline, there were no deaths prior to ART initiation (no transition to this state).