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Acoustic pressure and microbubles used in the experiments
| In vitro human skull | In vivo NHP | |
|---|---|---|
| Derated Pressure∗ | 0.1 MPa | 0.3 MPa |
| Microbubble | In-house polydisperse | Definity |
| MB concentration | 5 × 108bubbles/ml | 1.2 × 1010bubbles/ml |
| MB dose | N/A | 0.05 ml/kg |
We assumed the skull insertion loss of 60% and 50% for in vitro human skull and in vivo NHP experiments, respectively.
