Figure 1.

The role of peptide induced immune tolerance in SLE. A: In the autoimmune state, the CD4⁺ and CD8⁺ T cells are activated, and Dendritic cells (DCs) become aggressive and create autoimmune activation and further inflammation in SLE. B: In the tolerance state, peptide-induced tolerization promotes the expansion of antigen-specific regulatory cells and further tolerizes dendritic cells (DCs). These tolerized dendritic cells induce deletion and anergy of cognate T cells and further modulate regulatory T cells in SLE. These peptide induced regulatory T cells (T_regs) which suppress the autoreactive/autoimmune responses in SLE.