Table 1.
The action pathway of ferroptosis core gene
| Suppressor | Driver | |
|---|---|---|
| Iron absorption and efflux | Tfr1, Tfr2, DMT1 | |
| Iron storage | Ferritin | |
| Ferriregulatory protein | FBXL5 | IRP1, IRP2 |
| Heat shock protein | HSF-1, HSBP1, HSPA5 | |
| Iron autophagy regulatory factor | NCOA4 | |
| Redox-regulated | NRF2, GPX4, FSP1, HO-1 NQO1, CISD1 |
ALOXs, PEBP1, NOXs DPP4/CD26, VDAC2/3 |
| Glutathione steady-state regulation | SLC7A11, MUC1, GCLC | SLC1A5, GLS2, CARS, CHAC1 |
| Lipid metabolism regulation | LSH/HELLS, SCD, FADS2 | ACSL4, ACSL3, LPCAT3, CS |
| Regulation of glucose metabolism | PHGDH, G6PD, ME1 | PHKG2 |
| The mevalerate pathway | HMGCR | SQLE, SQS |
| Transcription factor | STAT3, ATF4, HIF1A | ATF3, BACH1, P53, ATF4, HIF1A, ZEB1, NRF2, YAP/TAZ |
DPP4, dipeptidyl peptidase 4, LSH, lymphoid-specific helicase.