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. 2023 Sep 28;12:RP86721. doi: 10.7554/eLife.86721

Figure 3. CDCA7 homologs and other zf-4CXXC_R1-containing proteins in Arabidopsis.

Top; alignments of the zf-4CXXC_R1 domain found in Arabidopsis thaliana. Bottom; domain structure of the three classes of zf-4CXXC_R1-containing proteins in Arabidopsis.

Figure 3.

Figure 3—figure supplement 1. Sequence alignment and classification of zf-4CXXC_R1 domains across eukaryotes.

Figure 3—figure supplement 1.

CDCA7 orthologs are characterized by the class I zf-4CXXC_R1 domain, where eleven cysteine residues and three residues mutated in ICF patients are conserved. Class II zf-4CXXC_R1 domain is similar to class I except that ICF-associated glycine (G294 in human) is substituted. Class III is zf-4CXXC_R domain with more substitutions at the ICF-associated residues (R274 and/or G294). Proteins that also contain JmjC domain (sequence not shown here) are indicated. Note that codon frame after the stop codon (an asterisk in a magenta box) of Naegleria XP_002678720 encodes a peptide sequence that aligns well with human CDCA7, indicating that the apparent premature termination of XP_002678720 is likely caused by a sequencing or annotation error.