TABLE 2.

Effect of MMF on the antiherpesvirus activity of GCV, ACV, or PCV in Vero cells

Virus	Antiviral agent	EC50 (μg/ml)a
		GCV alone	ACV alone	PCV alone	With MMF at 50 μg/ml	With MMF at 25 μg/ml	With MMF at 10 μg/ml	With MMF at 2.5 μg/ml	With MMF at 1.0 μg/ml
HSV-1	GCV	0.53 ± 0.11			0.021 ± 0.011	0.014 ± 0.004	0.016 ± 0.006	0.019 ± 0.009	0.022 ± 0.000
	ACV		2.45 ± 2.19		0.030 ± 0.020	0.030 ± 0.020	0.030 ± 0.020	0.056 ± 0.006	0.117 ± 0.033
	PCV			6.2 ± 1.54	0.20 ± 0.07	0.24 ± 0.06	0.25 ± 0.07	0.37 ± 0.17	0.26 ± 0.11
HSV-2	GCV	0.51 ± 0.38			0.002 ± 0.001	0.006 ± 0.003	0.010 ± 0.000	0.010 ± 0.002	0.076 ± 0.005
	ACV		1.30 ± 0.71		0.010 ± 0.000	0.033 ± 0.016	0.055 ± 0.026	0.085 ± 0.015	0.201 ± 0.011
	PCV			5.62 ± 1.55	0.008 ± 0.001	0.038 ± 0.053	0.040 ± 0.016	0.160 ± 0.010	1.18 ± 0.52
TK− HSV-1	GCV	10.64 ± 3.73			0.46 ± 0.24	0.46 ± 0.24	0.43 ± 0.26	0.66 ± 0.33	0.79 ± 0.00
	ACV		32.49 ± 4.74		0.13 ± 0.03	0.30 ± 0.20	0.36 ± 0.13	0.50 ± 0.00	0.75 ± 0.25
	PCV			≥100	1.4 ± 0.7	1.8 ± 0.8	2.1 ± 1.4	3.5 ± 1.6	4.9 ± 1.1

^aData are mean values for at least three separate experiments. The EC₅₀ of MMF alone is >50 μg/ml.