TABLE 5.
Effect of exogenously added guanosine on the potentiating effect of MPA on the anti-HSV-1 activity of ACV, GCV, or PCV in Vero cells
| Anti- viral agent | EC50 (μg/ml)a
|
||||
|---|---|---|---|---|---|
| GCV alone | ACV alone | PCV alone | With MPA at 1.0 μg/ml | With MPA at 1.0 μg/ml + guanosine at 25 μg/ml | |
| GCV | 0.49 ± 0.19 | 0.015 ± 0.007 | 0.64 ± 0.07 | ||
| ACV | 4.15 ± 4.0 | 0.09 ± 0.06 | 1.2 ± 0.2 | ||
| PCV | 2.9 ± 0.3 | 0.14 ± 0.0 | 3.15 ± 0.6 | ||
a
The EC50s for inhibition of HSV-1-induced CPE by MPA and guanosine were >25 μg/ml and >100 μg/ml, respectively.