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. 1998 Feb;42(2):216–222. doi: 10.1128/aac.42.2.216

TABLE 5.

Effect of exogenously added guanosine on the potentiating effect of MPA on the anti-HSV-1 activity of ACV, GCV, or PCV in Vero cells

Anti- viral agent EC50 (μg/ml)a
GCV alone ACV alone PCV alone With MPA at 1.0 μg/ml With MPA at 1.0 μg/ml + guanosine at 25 μg/ml
GCV 0.49 ± 0.19 0.015 ± 0.007 0.64 ± 0.07
ACV 4.15 ± 4.0 0.09 ± 0.06 1.2 ± 0.2
PCV 2.9 ± 0.3 0.14 ± 0.0 3.15 ± 0.6
a

The EC50s for inhibition of HSV-1-induced CPE by MPA and guanosine were >25 μg/ml and >100 μg/ml, respectively.