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. Author manuscript; available in PMC: 2024 Oct 1.
Published in final edited form as: Int Ophthalmol Clin. 2023 Sep 27;63(4):33–60. doi: 10.1097/IIO.0000000000000479

Table 1.

Currently available Minimally Invasive Glaucoma Surgery (MIGS) devices and approaches.

Name Manufacturer MIGS Type IOP reduction (%)* Reduction in No. of Medications* Study Data Available* AAO Recommendation Cochrane recommendation
iStent (1st generation)
Glaukos, Laguna Hills, CA Non-Bleb Forming, Trabecular Meshwork Canal Implant 8.2 – 27.3** 0.35 – 2.2** Prospective and Retrospective No Recommendation Very Low°
iStent inject Glaukos, Laguna Hills, CA Non-Bleb Forming, Trabecular Meshwork Canal Implant 15.8 – 48.4 1.2 – 2.4 Prospective and Retrospective I-, Insufficient Quality, Strong Recommendation Very Low°
iStent infinite Glaukos, Laguna Hills, CA Non-Bleb Forming, Trabecular Meshwork Canal Implant 20.5 – 30.3 2.21 – 3.99 Prospective Not Evaluated Not Evaluated
Hydrus Alcon, Fort Worth, TX Non-Bleb Forming, Trabecular Meshwork Canal Implant 8.9 – 30.7 1.0 – 2.8 Prospective and Retrospective I, Moderate Quality, Strong Recommendation Moderate°
Trabectome MicroSurgical Technology, Redmond, WA Non-Bleb Forming, Trabecular Meshwork Canal Cleaving Approaches 18–42 0 – 1.2 Prospective and Retrospective No Recommendation Very Low
Kahook Dual Blade New World Medical, Rancho Cucamonga, CA Non-Bleb Forming, Trabecular Meshwork Canal Cleaving Approaches 6.2 – 48.8 0.5 – 2.2 Prospective and Retrospective No Recommendation Not Evaluated
Gonioscopy-assisted transluminal trabeculotomy NA Non-Bleb Forming, Trabecular Meshwork Canal Cleaving Approaches 36.2 – 68.2 1.1 – 3.5 Retrospective No Recommendation Not Evaluated
OMNI Sight Sciences, Menlo Park, CA Non-Bleb Forming, Trabecular Meshwork Canal Dilating & Cleaving Approaches 19.2 – 44.7 0.0 – 2.5 Prospective and Retrospective No Recommendation Not Evaluated
ABiC with iTrack Nova Eye Medical, Kent Town, Australia Non-Bleb Forming, Trabecular Meshwork Canal Dilating Approaches 32.5 – 39.2 0.9 −2.6 Prospective and Retrospective No Recommendation Not Evaluated
ECP Endo Optiks, Little Silver, NJ Non-Bleb Forming, Inflow Reducing Approaches 34 – 57 0.0 – 1.5 Retrospective I-, Insufficient Quality, Discretionary Recommendation Evaluated, no recommendation
Xen Gel Stent AbbVie Inc., North Chicago, Illinois Bleb-Forming, Ab Interno Implants 22.9 – 57.9 0.9 – 3.5 Prospective and Retrospective I-, Insufficient Quality, Discretionary Recommendation Evaluated, no recommendation
*

Either standalone or with concurrent phacoemulsification.

**

Depending on the number of implanted stents.

°

Only RCTs analyzed.

One RCT only.

AAO: American Academy of Ophthalmology; ABiC: Ab Interno Canaloplasty; ECP: Endoscopic cyclophotocoagulation; IOP: Intraocular Pressure