Table 2:
Association of baseline frailty class with risk of adverse clinical outcomes
| Event Rate | Model 1 | Model 2 | |||
|---|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | ||
| Primary outcome (HF hospitalization or death) | |||||
| Non-Frail (FI Class I) | 22.7% | Referent | |||
| Intermediate Frailty (FI Class II) | 33.0% | 1.60 (1.08–2.39) | 0.02 | 1.42 (0.94– 2.16) | 0.10 |
| High Frailty (FI Class III) | 43.2% | 2.31 (1.62–3.30) | <0.001 | 1.76 (1.20–2.58) | 0.004 |
| All-cause mortality | |||||
| Non-Frail (FI Class I) | 5.52% | Referent | |||
| Intermediate Frailty (FI Class II) | 12.7% | 2.09 (0.98–4.44) | 0.06 | 1.58 (0.73–3.40) | 0.24 |
| High Frailty (FI Class III) | 20.8% | 3.72 (1.87–7.40) | <0.001 | 2.55 (1.25– 5.20) | 0.01 |
| Heart failure hospitalization | |||||
| Non-Frail (FI Class I) | 21.5% | Referent | |||
| Intermediate Frailty (FI Class II) | 29.0% | 1.50 (0.99– 2.27) | 0.06 | 1.34 (0.87–2.08) | 0.18 |
| High Frailty (FI Class III) | 37.6% | 2.14 (1.48– 3.09) | <0.001 | 1.61 (1.08–2.40) | 0.02 |
Model 1: Adjusted for age, sex, race (white), treatment arm, baseline body mass index
Model 2: Model 1 + baseline ejection fraction + heart failure etiology+ baseline NT-proBNP + NYHA class + history of atrial fibrillation
Abbreviations: CI, confidence interval; HR, hazard ratio; HF, heart failure