Skip to main content
. Author manuscript; available in PMC: 2024 Oct 1.
Published in final edited form as: Addict Biol. 2023 Oct;28(10):e13332. doi: 10.1111/adb.13332

Table 1.

List of 27 substance-associated neurotransmitter binding genes that are differentially regulated in AddictRegions. These include 22 up-regulated genes and 5 genes that were down-regulated only. Fold changes are expressed as log2-transfromed values. AlcUse, alcohol use; AUD; alcohol use disorder; TobIni, tobacco initiation; TobUse, tobacco use; TUD, tobacco use disorder.

Gene OFG MFG SFG IFG CgG Ins Hpc Amg GP DS NAc Hyp Tha SN VTA PAG Substance References
CHRM2 −1.2 −1.4 −1.3 −1.1 −1.3 −2.1 −1.2 −2.3 −1.3 1.3 −2.2 AlcUse 34
CHRNA2 −1.1 3.6 TobIni 25
CHRNA3 −2.3 −2.5 −2.3 −2.4 −1.9 −2.1 −1.5 0.0 −1.6 −1.1 2.0 TobUse 25,29,30,32,34
CHRNA4 −2.0 −1.5 1.1 2.0 1.8 2.1 TobIni, TobUse, TUD 13,25,29,31,32,34
CHRNA5 1.2 1.4 TobUse 25,31
CHRNA6 −1.1 −1.4 1.5 1.1 TobUse 34
CHRNA7 −1.2 −1.2 1.0 AlcUse 34
CHRNB2 1.3 1.3 TobUse 25,31,34
CHRNB3 −1.3 −1.1 −1.1 2.6 2.7 TobUse, TUD 13,25,31,32,34
DRD2 1.2 1.3 3.1 2.7 2.1 2.3 2.1 2.5 AlcUse, AUD, TobUse 25–28,31,34
GABRA4 1.2 1.3 1.4 1.2 1.1 1.4 1.0 1.1 −1.7 1.6 1.7 −1.3 1.1 −1.3 AlcUse 34
GABRA6 −5.4 −5.9 −5.7 −5.2 −5.0 TobIni 25
GABRB1 1.4 1.4 1.5 1.1 TobIni 34
GABRB2 −1.4 TobIni 34
GABRG1 1.5 1.3 1.2 1.7 1.6 AlcUse, TobIni 34
GLRA3 1.4 −1.4 1.0 1.4 1.2 1.3 AlcUse, TobIni 34
GRIA4 −1.7 −1.3 −1.1 −1.8 −1.4 −1.0 TobIni 34
GRID1 1.1 AlcUse, TobIni 34
GRID2 −1.2 −1.1 −1.1 −1.1 −1.1 −1.7 −1.5 −1.1 TobIni 25,29,34
GRIK2 −1.1 −1.1 −1.1 −1.3 −1.3 TobIni 34
GRIN2A 1.2 1.3 1.2 1.3 1.1 1.1 1.5 −1.2 −1.1 −2.1 −1.4 TobIni 25,34
GRIN2B 1.3 1.2 1.3 1.4 1.6 1.9 −1.4 1.8 1.7 −1.0 1.4 AlcUse, TobIni 34
GRM5 1.1 1.1 1.8 1.5 −1.1 1.4 AlcUse, TobIni 34
HTR2A 1.7 1.9 2.0 1.6 1.4 −1.4 −1.1 −2.6 −2.5 −2.0 −1.2 −1.8 −1.2 −1.1 TobIni 34
HTR4 1.8 0.0 2.2 1.9 −1.2 −1.1 0.2 TobIni 34
LY6H 1.9 1.8 1.8 3.0 2.5 2.5 TobIni 34
OPRM1 −1.2 −1 −1.2 −1.5 1.1 1.3 TobIni 34