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. Author manuscript; available in PMC: 2023 Sep 28.
Published in final edited form as: N Engl J Med. 2023 Sep 28;389(13):1191–1202. doi: 10.1056/NEJMoa2210956

Fig. 3. Genome-wide phylogenetic tree.

Fig. 3.

This maximum-likelihood tree is based on 128 P. falciparum Eritrean isolates (red), together with 162 isolates collected worldwide (Africa, Asia and South America) and the 3D7 reference genome from Africa. Labels of Eritrean isolates include the year of collection. The non-Eritrean isolates were sourced from the MalariaGEN P. falciparum Community Project (https://www.malariagen.net/apps/pf/4.0) and are labelled with their accession identifier. Each leaf represents one sample and is colored according to the country of collection (bottom). Eritrean parasites carrying the Pfkelch13 622I mutation are identified by filled red stars at the tip. Eritrean Pfkelch13 622I mutants are closely related to Pfkelch13 wild type parasites originating from East African countries. Scale bar, 0.00005 nucleotide substitutions per character.