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. 2023 Aug 26;37(10):2082–2093. doi: 10.1038/s41375-023-02003-x

Fig. 3. Clonal architecture of myeloid neoplasms with -7/del7q.

Fig. 3

A Exemplary cases of -7/del7q dominant (upper), secondary (middle), and co-dominant with somatic variants (lower). Reconstruction of the clonal hierarchy was analyzed using an allelic imbalance for WES samples and CNV analyses for WGS. Figures were created with BioRender.com. B Distribution of dominant or secondary -7/del7q hit in -7/del7q MN cases without complex karyotype (CK). C Dominant somatic mutational distribution in secondary -7/del7q cases without CK. D Distribution of dominant, secondary, or co-dominant -7/del7q hit in CK -7/del7. E TP53 mutation was dominant hit in most of -7/del7q cases with CK.