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. 2023 Aug 26;37(10):2082–2093. doi: 10.1038/s41375-023-02003-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A Flowchart for selecting HI genes using mRNA-sequencing data of 49 -7/del7q and 120 normal karyotype (NK) cases B ZNF277 was shown as an example of selected HI genes. ZNF277 expression levels of NK cases, -7/del7q before adjustment, and -7/del7q after adjustment were shown (left). Each expression level of -7/del7q cases was adjusted to 100% clonality using the slopes from estimated linear model (right). C Six common HI genes fitted our HI definition. D Correlation between copy number variation (CNV) and gene expression in 6 well-known HI genes.