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. 2023 Aug 26;37(10):2082–2093. doi: 10.1038/s41375-023-02003-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — A Flowchart (left) for selecting the genes, CRISPR/shRNA knockout (KO) of which showed significant cell growth inhibition or a trend towards cell proliferation. Graphic (right) depicting the differentially gene expression levels between -7/del7q and NK myeloid neoplasms of the 199 HI genes in the CDRs identified by molecular mapping and the effect of shRNA or CRISPR KO of the 199 HI genes on cell proliferation from DepMap public database (https://depmap.org/portal/). B Summary of 199 HI genes based on lethality in KO mice collected from literature review, vulnerability of leukemia cells by CRISPR/shRNA KO screens from DepMap database, and the presence of cases affected by hemizygous or homozygous LOF mutations in our cohort. The numbers in brackets indicate the number of cases with each hemizygous or homozygous mutation in our cohort.