Table 1:

Effect of zibotentan, dapagliflozin and the combination on baseline corrected Hb.

		Zibo	Zibo	Dapa	Zibo (30 mg/kg) +	Zibo (100 mg/kg) +
Parameters	Vehicle	(30 mg/kg)	(100 mg/kg)	(3 mg/kg)	Dapa (3 mg/kg)	Dapa (3 mg/kg)
Basal Hb (g/L)	159.4 ± 2.44	160.2 ± 1.62	158.5 ± 2.00	157.9 ± 2.34	159.3 ± 2.17	158.7 ± 1.04
Day 3 Hb (g/L)	159.1 ± 2.20	144.4 ± 2.32*	147.5 ± 1.96*	164.4 ± 1.42	151.3 ± 1.62*	152.4 ± 1.02
Day 7 Hb (g/L)	157.5 ± 1.91	148.6 ± 1.86*	144.8 ± 1.69*	159.1 ± 1.88	149.7 ± 2.80	152.9 ± 1.99

Effect of 30 mg/kg and 100 mg/kg zibotentan with or without 3 mg/kg dapagliflozin, 3 mg/kg dapagliflozin alone and vehicle on Hb. N = 8–12/group, *P < .05 vs vehicle. Data analysis used one-way ANOVA, and Tukey's test for multiple comparisons. Data presented as mean ± SEM.