Table 2.
Results from Cox proportional hazards models on deaths from colorectal cancers, fitted with the covariates in the table, in univariate Cox regression (left) and together in a multivariate model (right).
| Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|
| Hazard ratio (95% confidence interval) | p value | Hazard ratio (95% confidence interval) | p value | |
| Intermediate amount of tumour stroma (10–50%) | 1.34 (1.10–1.62) | <2.2 × 10–16*** | 1.18 (0.97–1.44) | 1.18 × 10–6*** |
| High amount of tumour stroma (>50%) | 2.71 (2.25–3.27) | 1.64 (1.35–2.00) | ||
| High lymphocytic infiltration at the tumour margin | 0.44 (0.35–0.55) | 1.6 × 10–15*** | 0.74 (0.59–0.94) | 0.0095* |
| Presence of lymphoid follicles in tumour | 0.51 (0.40–0.64) | 3.8 × 10–10*** | 0.68 (0.54–0.87) | 0.001** |
| Tumour proximal to splenic flexure | 1.47 (1.27–1.70) | 2.7 × 10–7*** | 1.27 (1.09–1.47) | 0.002** |
| Age at diagnosis | 1.02 (1.01–1.03) | 4.6 × 10–8*** | 1.03 (1.02–1.04) | <2.2 × 10–16*** |
| TNM stage II | 3.37 (1.98–5.74) | <2.2 × 10–16*** | 2.47 (1.45–4.22) | <2.2 × 10–16*** |
| TNM stage III | 7.79 (4.63–13.11) | 6.16 (3.65–10.42) | ||
| TNM stage IV | 39.18 (23.26–65.97) | 28.60 (16.84–48.54) | ||
| Year of diagnosis | 0.97 (0.96–0.97) | <2.2 × 10–16*** | 0.96 (0.96–0.97) | <2.2 × 10–16*** |
| Female sex | 1.00 (0.86–1.15) | 0.97 | Not included | |
| Lynch syndrome | 0.49 (0.24–0.98) | 0.02 | Not included | |
| Prior cancer diagnosis | 1.03 (0.82–1.29) | 0.79 | Not included | |
p Values are results from likelihood ratio tests. For the univariate analysis, statistical significance is indicated with * for p values <5 × 10–3, ** for p values <5 × 10–4 and *** for p values <5 × 10–5 after adjustment for the number of hypothesis (10). For the multivariate analysis, statistical significance is indicated with * for p values <5 × 10–2, ** for p values <5 × 10–3 and *** for p values <5 × 10–4.