Table 1.
Class | Category | Person-years | Persons first at riska | Myeloid malignant neoplasms | AML | AML + MDS | CML | ALL | Acute leukaemia | Leukaemia excluding CLL, unclassified as AML/CML/ALL | Leukaemia excluding CLL |
---|---|---|---|---|---|---|---|---|---|---|---|
Total | 7,641,362 | 310,905 | 274 | 140 | 158 | 61 | 71 | 243 | 93 | 365 | |
Sex | Male | 3,332,630 | 154,647 | 146 | 73 | 83 | 34 | 36 | 123 | 53 | 196 |
Female | 4,306,530 | 156,036 | 128 | 67 | 75 | 27 | 34 | 119 | 40 | 168 | |
Unknown | 2204 | 222 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | |
Entry year | <1920 | 56 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
1920–1929 | 37,505 | 576 | 2 | 1 | 1 | 1 | 0 | 3 | 2 | 4 | |
1930–1939 | 170,704 | 4115 | 11 | 1 | 1 | 3 | 0 | 1 | 10 | 14 | |
1940–1949 | 170,857 | 4638 | 3 | 0 | 0 | 2 | 1 | 2 | 12 | 15 | |
1950–1959 | 5,077,780 | 118,126 | 205 | 117 | 124 | 47 | 43 | 184 | 55 | 262 | |
1960–1969 | 300,211 | 6372 | 4 | 2 | 3 | 1 | 0 | 2 | 4 | 7 | |
1970–1979 | 263,511 | 9307 | 5 | 2 | 4 | 0 | 1 | 7 | 6 | 9 | |
1980–1989 | 50,382 | 2701 | 1 | 1 | 1 | 0 | 2 | 3 | 0 | 3 | |
1990–1999 | 1,056,900 | 84,058 | 32 | 10 | 17 | 6 | 16 | 26 | 2 | 34 | |
≥2000 | 513,463 | 81,010 | 11 | 6 | 7 | 1 | 8 | 15 | 2 | 17 | |
Age at entry (years)a | 0–4 | 1,427,710 | 56,366 | 34 | 17 | 23 | 6 | 17 | 42 | 12 | 52 |
5–9 | 1,905,370 | 60,555 | 64 | 34 | 38 | 11 | 25 | 63 | 14 | 84 | |
10–14 | 1,519,830 | 58,714 | 58 | 28 | 33 | 17 | 9 | 45 | 14 | 68 | |
15–19 | 1,177,090 | 62,903 | 52 | 29 | 30 | 12 | 5 | 36 | 10 | 56 | |
20–29 | 1,343,570 | 61,245 | 51 | 29 | 30 | 12 | 14 | 49 | 19 | 74 | |
30–39 | 191,916 | 6497 | 5 | 2 | 2 | 1 | 1 | 6 | 10 | 14 | |
40–49 | 51,260 | 2357 | 6 | 1 | 2 | 1 | 0 | 2 | 8 | 10 | |
≥50 | 24,614 | 2268 | 4 | 0 | 0 | 1 | 0 | 0 | 6 | 7 | |
Years since first exposurea | <0 or NA | 1,667,610 | 50,335 | 68 | 27 | 31 | 16 | 10 | 44 | 41 | 94 |
0–0.99 | 23,335 | 19,912 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | |
1–1.99 | 25,243 | 2208 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
2–4.99 | 568,364 | 167,316 | 10 | 5 | 7 | 2 | 10 | 19 | 6 | 23 | |
5–9.99 | 1,052,290 | 56,331 | 29 | 14 | 15 | 8 | 19 | 36 | 5 | 46 | |
10–14.99 | 745,666 | 7630 | 24 | 9 | 13 | 4 | 9 | 21 | 7 | 29 | |
15–19.99 | 529,238 | 2890 | 14 | 9 | 10 | 3 | 5 | 15 | 3 | 20 | |
20–29.99 | 865,351 | 2537 | 21 | 12 | 12 | 8 | 6 | 23 | 6 | 32 | |
≥30 | 2,164,270 | 1746 | 107 | 63 | 69 | 20 | 12 | 84 | 25 | 120 | |
Attained age (years)a | 0–4.99 | 124,753 | 56,366 | 1 | 1 | 1 | 0 | 4 | 6 | 1 | 6 |
5–9.99 | 411,538 | 60,555 | 5 | 4 | 5 | 0 | 13 | 20 | 5 | 22 | |
10–14.99 | 623,591 | 58,714 | 12 | 5 | 6 | 5 | 11 | 18 | 2 | 23 | |
15–19.99 | 778,480 | 62,903 | 23 | 10 | 12 | 5 | 5 | 20 | 7 | 27 | |
20–29.99 | 1,731,430 | 61,245 | 36 | 19 | 23 | 9 | 12 | 39 | 12 | 52 | |
30–39.99 | 1,281,480 | 6497 | 28 | 14 | 14 | 9 | 6 | 20 | 7 | 36 | |
40–49.99 | 1,152,100 | 2357 | 42 | 21 | 22 | 12 | 6 | 33 | 12 | 51 | |
≥50 | 1,537,990 | 2268 | 127 | 66 | 75 | 21 | 14 | 87 | 47 | 148 | |
Mean cumulative active bone marrow dose (Gy) | 0 | 2,832,010 | 93,729 | 106 | 51 | 55 | 26 | 13 | 76 | 53 | 143 |
0–0.004 | 964,831 | 65,125 | 24 | 10 | 10 | 6 | 1 | 14 | 5 | 22 | |
0.005–0.099 | 628,876 | 50,911 | 14 | 5 | 7 | 5 | 6 | 13 | 5 | 21 | |
0.010–0.019 | 669,905 | 48,357 | 11 | 6 | 8 | 1 | 15 | 22 | 3 | 25 | |
0.020–0.049 | 534,468 | 21,414 | 24 | 15 | 19 | 3 | 8 | 24 | 3 | 29 | |
0.050–0.099 | 425,622 | 10,015 | 16 | 12 | 12 | 2 | 4 | 19 | 4 | 22 | |
0.100–0.149 | 244,034 | 4946 | 12 | 5 | 5 | 3 | 2 | 9 | 5 | 15 | |
0.150–0.199 | 127,858 | 2761 | 9 | 6 | 8 | 0 | 1 | 8 | 2 | 9 | |
0.200–0.299 | 191,887 | 3918 | 3 | 0 | 0 | 3 | 1 | 2 | 2 | 6 | |
0.300–0.499 | 347,124 | 4788 | 9 | 3 | 4 | 2 | 4 | 7 | 2 | 11 | |
0.500–0.749 | 365,219 | 2206 | 16 | 8 | 10 | 3 | 5 | 14 | 3 | 19 | |
0.750–0.999 | 186,260 | 1211 | 8 | 4 | 4 | 2 | 2 | 10 | 4 | 12 | |
1.000–1.499 | 74,472 | 754 | 6 | 5 | 5 | 1 | 3 | 9 | 1 | 10 | |
1.500–1.999 | 29,564 | 326 | 8 | 6 | 7 | 0 | 0 | 6 | 1 | 7 | |
2.000–2.499 | 8232 | 178 | 4 | 2 | 2 | 2 | 0 | 2 | 0 | 4 | |
2.500–2.999 | 5708 | 158 | 2 | 1 | 1 | 1 | 4 | 5 | 0 | 6 | |
3.000–4.999 | 5241 | 107 | 2 | 1 | 1 | 1 | 2 | 3 | 0 | 4 | |
5.000–7.499 | 53 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
AML acute myeloid leukaemia, CML chronic myeloid leukaemia, ALL acute lymphoblastic leukaemia.
aThe number of persons represents those first entering follow-up in the given categories (of attained age, time since first exposure etc.).