Figure 3.

Diagnostic accuracy indices for meta-analysis of the combinations of miRNAs. (a) sensitivity and specificity of biofluid-derived microRNAs with corresponding estimates for heterogeneity I2 tests (n = 15 studies). The sensitivity or specificity for each study is represented by the black circles in the grey square and the 95% confidence interval for each study is represented by the associated horizontal lines. (b) positive and negative likelihood ratios: PLR/NLR is represented by the black circles in the grey squares and the 95% confidence interval for each study is represented by the associated horizontal lines (c) diagnostic score and diagnostic odds ratio: the diagnostic score/DOR are represented by the black circles in the grey squares and the 95% confidence interval for each study is represented by the associated horizontal lines. The pooled estimate is represented by the diamonds with the horizontal edges of the diamonds reflecting the 95% confidence interval. The red dotted line represents the pooled average point estimate. The studies are ordered by biofluid type: Serum^1–7, Plasma^8–11, CSF^12,13, PBMC¹⁴ and Saliva¹⁵. (d) Summary Receiver Operating Characteristic curve of biofluid-derived microRNAs in PD patients compared to controls (n = 15 studies). The red filled diamond represents the summary estimate of the test accuracy, and the dotted line denoting the 95% confidence region around this estimate. The circles represent each study involved in the meta-analysis: 1²⁹, 2³⁰, 3³¹, 4³³, 5³⁴, 6³⁸, 7⁴³, 8³², 9⁴¹, 10⁴², 11⁴⁴, 12³⁵, 13³⁹, 14³⁶, 15³⁷.